Anticodon binding domain F

The anticodon binding domain F recognises the tRNA anticodon loop (Klipcan et al. 2010, Pouplana and Schimmel, 2001). This compact domain consists of a three-stranded $\beta$ sheet and two $\alpha$-helices. It resides at the C-termini of two PheRS families: the $\beta$ subunit of the bacterial-like [PheRS-B](/class2/phe2/), and the monomeric mitochondrial-like [PheRS-M](/class2/phe5/). The domain does not appear in the eukaryotic/archaeal cytosolic form [PheRS-A](/class2/phe4/).

References

Klipcan, Liron, et al. "Structural aspects of phenylalanylation and quality control in three major forms of phenylalanyl-tRNA synthetase." Journal of amino acids 2010 (2010) de Pouplana, Lluı́s Ribas, and Paul Schimmel. "Aminoacyl-tRNA synthetases: potential markers of genetic code development." Trends in biochemical sciences 26.10 (2001): 591-596.