Anticodon binding domain (CRIMVL)
The anticodon binding domain CRIMVL is an $\alpha$-helical protein. It resides at the C-termini of several Class I AARS: [CysRS](/class1/cys/), [ArgRS](/class1/arg/), [IleRS](/class1/ile/), [MetRS](/class1/met/), [ValRS](/class1/val/), [LeuRS-A](/class1/leu2/), and [LeuRS-B](/class1/leu1/), where it recognises the tRNA anticodon loop, approaching the acceptor stem from the minor groove side (de Pouplana and Schimmel, 2001).