Anticodon binding domain (WY)

The anticodon binding domain WY is a short $\alpha$-helical structure. It resides at the C-termini of [TrpRS](/class1/trp/) and the archaeal and eukaryotic forms of [TyrRS](/class1/tyr). The domain undergoes substantial conformational changes upon tRNA binding (Shen et al. 2008).

References

Charles W Carter. "The Aminoacyl-tRNA Synthetases" CRC Press (2005): Chapter 11: Tryptophanyl-tRNA Synthetases. Shen, Ning, et al. "Catalytic mechanism of the tryptophan activation reaction revealed by crystal structures of human tryptophanyl-tRNA synthetase in different enzymatic states." Nucleic acids research 36.4 (2008): 1288-1299.